The use of immunobiological monoclonal antibody-based drugs in nephrological practice

Authors

  • O.O. Melnyk Specialized Medical Center “Optima-Pharm”, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2307-1257.7.3.2018.140208

Keywords:

kidney diseases, monoclonal antibodies, rituximab, eculizumab, burosumab, adalimumab, abatacept, fresolimumab

Abstract

With various diseases of the kidneys, immunobiological monoclonal antibody-based therapy with a different mechanism of action is successfully used. These drugs include: rituximab (interaction with the CD20 receptor and elimination of B cells), eсulizumab (inhibition of C5 complement clea­vage), burosumab (blocking fibroblast growth factor 23), adalimumab (anti-tumor necrosis factor α agent), abatacept (blocks co-stimulation of T cells by binding to CD80), fresolimumab (neutralization of transforming growth factor β). These drugs are used for systemic kidney diseases, focal segmental glomerulosclerosis, lupus nephritis, membranous nephropathy, kidney transplantation.

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Published

2021-09-08

How to Cite

Melnyk, O. (2021). The use of immunobiological monoclonal antibody-based drugs in nephrological practice. KIDNEYS, 7(3), 224–236. https://doi.org/10.22141/2307-1257.7.3.2018.140208

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Vol. 7 No. 3 (2018)

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Reviews

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