The role of levocarnitine in the systemic therapy of patients of different profile of patients on chronic hemodialysis
DOI:
https://doi.org/10.22141/2307-1257.0.1.07.2014.76553Keywords:
L-carnitine, chronic kidney disease, chronic renal failure, therapy with L-carnitine in NephrologyAbstract
The paper presents the pharmacological characteristics of L-carnitine and evaluation of the effectiveness of its application in nephrology practice. Discussed the evidence of the use of levocarnitine for chronic kidney disease and chronic renal failure.
Downloads
References
Levocarnitine — Compound Summary // PubChem. The National Library of Medicine. — 01.06.2005.
Berg J.M. Biochemistry. — 5th ed. — WH Freeman and Company, 2002. — 476 р. ISBN 0-7167-4684-0.
Carnitine (L-carnitine). — University of Maryland Medical Center. http://umm.edu/health/medical/altmed/supplement/carnitine-lcarnitine#ixzz2rihuKRqv
Ferrari R., Merli E., Cicchitelli G., Mele D., Fucili A., Ceconi C. Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review // Ann. NY Acad. Sci. — 2004 Nov. — 1033. — 79-91.
Tom L. Broderick, George Panagakis, Denise DiDomenico, James Gamble, Gary D. Lopaschuk, Austin L. Shug, Dennis J. Paulson. L-Carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts // Cardiovasc. Res. — 1995. — 30(5). — 815-820. doi: 10.1016/S0008-6363(95)00111-5.
James J. DiNicolantonio, Carl J. Lavie, Hassan Fares, Arthur R. Menezes, and James H. O’Keefe. L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis // Mayo Foundation for Medical Education and Research // Mayo Clin. Proc. — 2013.
Malaguarnera M., Gargante M.P., Russo C., Antic T., Vacante M., Malaguarnera M., Avitabile T., Li Volti G., Galvano F. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis — a randomized and controlled clinical trial // Am. J. Gastroenterol. — 2010 Jun. — 105(6). — 1338-45. doi: 10.1038/ajg.2009.719. Epub 2010 Jan 12.
Qian Jiang, Gang Jiang, Ke-qing Shi, Hong Cai, Yi-xin Wang, Ming-hua Zheng. Oral Acetyl-L-Carnitine treatment in hepatic encephalopathy: view of evidence-based medicine // Annals of Hepatology. — 2013. — 12(5). — 803-809.
Felker D., Lynn A., Wang S., Johnson D.E. Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity // Expert. Rev. Clin. Pharmacol. — 2014 Jan. 22 [Epub ahead of print].
Malaguarnera M., Cammalleri L., Gargante M.P., Vacante M., Colonna V., Motta M. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial // Am. J. Clin. Nutr. — 2007 Dec. — 86(6). — 1738-44.
Berni A, Meschini R., Filippi S., Palitti F., De Amicis A., Chessa L. L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells // Mutat Res. — 2008 Feb. 29. — 650(2). — 165-74. doi: 10.1016/j.mrgentox.2007.11.008. Epub 2007 Dec. 8.
Charles Chazot. Carnitine supplementation in hemodialysis patients. http://www.uninet.edu/cin2003/conf/chazot/chazot.html
Ahmad S. L-carnitine in dialysis patients // Semin. Dial. — 2001. — 14. — 209-217.
Hiatt W.R., Koziol B.J., Shapiro J.I., Brass E.P. Carnitine metabolism during exercise in patients on chronic hemodialysis // Kidney Int. — 1992. — 41. — 1613-1619.
Chazot C., Jean G., Vo Van C., Charra B., Terrat J.C., G.L. Serum carnitine as a marker of protein malnutrition (Abstract) // J. Am. Soc. Nephrol. — 1997. — 8. — 230A.
Constantin-Teodosiu D., Young S., Wellock F., Short A.H., Burden R.P., Morgan A.G., Greenhaff P.L. Gender and age differences in plasma carnitine, muscle strength, and exercise tolerance in haemodialysis patients // Nephrol. Dial. Transplant. — 2002. — 17. — 1808-1813.
Kudoh Y., Aoyama S., Torii T., Chen Q., Nagahara D., Sakata H., Nozawa A. Hemodynamic stabilizing effects of L-carnitine in chronic hemodialysis patients // Cardiorenal. Med. — 2013 Oct. — 3(3). — 200-7. doi: 10.1159/000355016. Epub 2013 Sep. 27.
Lynch K.E., Feldman H.I., Berlin J.A., Flory J., Rowan C.G., Brunelli S.M. Effects Of L-Carnitine On Dialysis-Related Hypotension And Muscle Cramps: A Meta-Analysis. Source // Am. J. Kidney Dis. — 2008 Nov. — 52(5). — 962-71. PMID: 18706751.
Debska-Slizien A., Kawecka A., Wojnarowski K., Prajs J., Malgorzewicz S., Kunicka D., Zdrojewski Z., Lysiak-Szydlowska W., Lipinski J., Rutkowski B. Correlation between plasma carnitine, muscle carnitine and glycogen levels in maintenance hemodialysis patients // Int. J. Artif. Organs. — 2000. — 23. — 90-96.
Labonia W.D. L-carnitine effects on anemia in hemodialyzed patients treated with erythropoietin // Am. J. Kidney Dis. — 1995. — 26. — 757-764.
Hurot J.M., Cucherat M., Haugh M., Fouque D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review // J. Am. Soc. Nephrol. — 2002. — 13. — 708-714.
National Kidney Foundation Carnitine Consensus Conference Practice Recommendations // American Journal of Kidney Diseases. — 2003. — 41. — 868-876.
Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation // Am. J. Kidney Dis. — 2000. — 35. — S1-140.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 M.D. Ivanova

This work is licensed under a Creative Commons Attribution 4.0 International License.
ISSN 2307-1257
ISSN 2307-1265
















